Short answer: most travelers flying directly from the US, UK, Canada, Australia or mainland Europe do not need a yellow fever certificate to enter Tanzania. If your journey involves arriving from, or transiting more than 12 hours through, a country with yellow fever risk, you will need one.
Tanzania requires proof of yellow fever vaccination — an International Certificate of Vaccination or Prophylaxis (ICVP, the "yellow card") — from travelers arriving from or transiting through countries with risk of yellow fever transmission. This includes most of sub-Saharan Africa (Kenya, Uganda, Ethiopia and Rwanda are common transit points for travelers connecting to Tanzania) and parts of South America.
The 12-hour transit rule matters: a short layover under 12 hours in a risk country, where you don't leave the airport, generally doesn't trigger the requirement. A longer layover, or leaving the airport for any reason, generally does.
If you're flying directly from a non-endemic country (the US, UK, most of Europe, Australia, Canada, etc.) with no stopover in a risk country, you do not need the certificate to enter — though the World Health Organization still recommends the vaccination for travelers' own protection, regardless of the entry requirement.
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